See how structural features of Prp43 allow translocation in the latest issue of RNA

Lab member Klaus Nielsen, along with the Andersen Lab at Aarhus University in Denmark, detail how structural changes in the ratchet domain of the DEAH-box ATPase Prp43 could allow translocation. Using genetics, biochemistry, and structural data, Klaus and colleagues show that two hairpins, as well as a dynamic motif, are implicated in allowing 3' to 5' movement along RNA. Interestingly, these data also reveal similarities between Prp43 and viral helicases.

Read more about this research in the journal RNA.